Property:Medicinal molecular basis description
From Biodiversity of India
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Pages using the property "Medicinal molecular basis description"
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|Barleria prionitis +||Indoid glycosides, Barlerin, Verbascoside from flower have potent activity against respiratory syntial virus, which may account for the plant's use in fever and respiratory diseases. The anti-spermatogenic effect of the root extract seems to be mediated by disturbances in the Leydig and Sertoli cells in testicles. +|
|Boerhavia diffusa +||The active principle active compound found in this herb is an alkaloid, known as punarnavine. +|
|Cocos nucifera +||Octanoic acid is one active compound and has antifungal activity against Candida and some other dermatophytes +|
|Curcuma longa +||Reduces beta amyloid plaques, Reduces amount of LDL. In HIV, Curcumin may act by interfering with P300/CREB-binding protein (CBP). Low concentrations may also inhibit Herpes Simplex Virus (HSV) by inhibiting the recruitment of RNA pol II to viral DNA. Curcumin prevents lipid oxidation by upregulating Glutathione S transferase, an antioxidant enzyme. It causes an upregulation of the Brain Derived Neurotropic Factor (BDNF) causing neurogenesis in the brain. '''More detailed mechanisms with references are noted on Wikipedia entry on Curcumin (See references)''' +|
|Garcinia cambogia +||Garcinia cambogia extract contains (−)-hydroxycitric acid (HCA) which is found to suppress body fat accumulation in developing male Zucker obese (fa/fa) rats. +|
|Glycyrrhiza glabra +||Hepatoprotective mechanisms of the active compound glycyrrhizic acid have been documented in mice (Lee, 2007) Recently researchers have demonstrated that doses of licorice root extract, delivering the constituent glycyrrhizin in amounts similar to that contained in standard medical doses of the root, rapidly and significantly lowered levels of circulating testosterone in males (Medherb) Glycyrrhizin inhibits liver cell injury caused by many chemicals and is used in the treatment of chronic hepatitis and cirrhosis in Japan. It also inhibits the growth of several DNA and RNA viruses, inactivating herpes simplex virus particles irreversibly. +|
|Hygrophila auriculata +||The molecular basis is not clearly understood. However, the alcoholic and aqueous extracts of seeds has been shown to be hepato-protective. Feeding diabetic mice with aerial parts of the plant also leads to increase in hepato-protective compounds such as Glutathione and enzymes such as Glutathione Peroxidase in the kidney and liver. This antioxidant action could be responsible for its popularity in liver-protective medicines. +|
|Mangifera indica +||Mangiferin, 1,3,6,7-tetrahydroxyxanthone-C2-beta-D-glucoside, is a xanthone derivative which has been proposed to have antiviral, antiproliferative and antioxidant properties. It has gastroprotective and anti-diabetic activities too. +|
|Mimusops elengi +||Alcohol extract of stem bark has potent diuretic activity in rats comparable to diuretic drug Furosemide. The drug increases Na+/K+ transporter activity and may be acting like a loop diuretic. +|
|Nelumbo nucifera +||Several studies performed using flower, leaf and seed extracts on mice have indicated that the extracts have antioxidant properties and are hepatoprotective. However, the molecular basis of the medicinal properties are yet not known. +|
|Phyllanthus emblica +||The fruit has a high concentration of Vitamin C (160 times more than apple). Vitamin C is an antioxidant and helps in boosting immunity to diseases. +|
|Rauvolfia serpentina +||Reserpine is reported to influence the concentration of glycogen, acetyl choline, g-amino butyric acid, nucleic acids and anti-diuretic hormone in brain +|
|Saraca indica +||The extract from bark has stimulatory activity on the ovarian tissue. It may be producing an estrogen like activity enhancing the repair of the endometrium and preventing bleeding. The extract from flowers has been shown in mice to have anti-skin cancer activity. +|
|Sesamum indicum +||>sesamol and sesaminol -- (phenolic antioxidants), >chlorosesamone (2-chloro- 5, 8-dihydroxy-3-3methyl-2-butenyl)-1, 4- naphthoquinone) -- (chlorinated red naphthoquinone pigment with antifungal activity) +|
|Withania somnifera +||biologically active components of this plant are alkaloids (isopelletierine, anaferine), steroidal lactones (withanolides, withaferins), saponins containing an additional acyl group (sitoindoside VII and VIII), and withanolides with a glucose at carbon 27 (sitoindoside IX and X). rich in iron. Flavanoids from this plant are thought to have anti-proliferative action due to their interaction with JAK-STAT pathway. Extracts are also known to have Hypoglycaemic and Hypolipidaemic Effects +|